![]() “We always thought there was too much light in the ICU all the time,” Zee said. She discussed research involving critical ailments in the ICU by Maas and colleagues (LaBuzetta JN, et al.). “Sleep and circadian disturbance have broad implications for disease expression and treatment.” “Unexpected to me, the heart rate was higher at night. “It has a significant effect on glucose had to secrete a lot more insulin to maintain glucose level,” Zee said. Recent research from Mason and colleagues showed that just one night of light exposure during nighttime sleep impairs cardiometabolic function, she said. “The odds ratio is fairly high where if you are exposed to light 3 hours before bedtime you are at higher risk for gestational diabetes.” “There’s no difference in gestational diabetes in regard to activity level, but there’s a difference in light exposure 3 hours before bedtime,” Zee said. ![]() Ongoing research from Minjee Kim, MD, also from Northwestern, shows that exposure to light at night increases the odds of diabetes in pregnancy (Paul M.), she said. “It’s pretty significant and begs the question whether they’re due to each other,” Zee said. Other research has shown that light at night in older age is associated with obesity, diabetes and hypertension. People in lower socioeconomic classes tend to live in large cities where there’s light from streetlamps.” Sleep could be the one modifiable factor that affects our biology widely, but also has social implications. “Sleeping with our lights on messes with our systems,” she continued. “We need more of this type of work to show that sleep and circadian interventions can be scalable to the population,” she said. This led to NIH supporting ENLITE PD, a trial investigating the use of light therapy to treat PD-related sleep disturbances, Zee said. Research has shown that sleep quality improved, and physical and motor activity was higher during the day in patients with Parkinson’s disease who were exposed to daytime bright light for 2 weeks. Natural light during the day has beneficial effects, while artificial light at night has disadvantages. Both natural and artificial light affect physical and mental health outcomes, including immune, cardiometabolic and cognitive function as well as mood and sleep quality, she said. Zee discussed the “power of light,” which combines sleep and circadian rhythm. Even though circadian disorder is the flagship of sleep-wake disorders, the wall clock does not equal your biological internal clock, yet we assume that it does in our clinical practice.” “Circadian biologists are looking at so many additional elements. “Clinicians think of circadian disruption as a disorder of the sleep-wake cycle,” she said. ![]() ![]() In her lecture about bridging circadian and sleep science to enhance health span, Zee, director of the Center for Circadian and Sleep Medicine at Northwestern University Feinberg School of Medicine in Chicago, said, “Sleep and circadian rhythm are inseparable. Zee, MD, PhD, said in her keynote address at the SLEEP meeting. INDANAPOLIS - Circadian disorder is the flagship of sleep-wake disorders, Phyllis C. If you continue to have this issue please contact to Healio
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